Switch studies in virologically suppressed patients

Switch PI/R to ETR
Etraswitch Study
Original article : PLoS One. 2014 Feb 4;9(2):e84676 – P Echeverria
Last update : 07/09/2015

Dr Anton Pozniak
Chelsea and Westminster Hospital
London, UK

  • Switch from a PI-based regimen to a once-daily combination based on ETR maintained undetectable VL during 48 weeks in virologically suppressed HIV-infected patients while lipid profile and patient satisfaction improved significantly


* 4 x 100 mg pills dissolved in water


  • Primary Endpoint: % HIV RNA < 50 c/mL, on-treatment and ITT, M=F
  • Secondary endpoints: change in CD4, CD8, metabolic parameters (lipids and glucose), safety, patient satisfaction

Baseline characteristics and disposition

Virologic and immunologic outcomes at W48

  • No difference in CD4 change

Metabolic parameters and satisfaction


  • No Grade3-4 clinical adverse events
  • No significant changes in liver enzymes in either group, no Grade 3-4 elevations


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